Exosome Therapy: What It Does and How It Rejuvenates Skin

Today we are sharing some "international medical news." Recently, "exosomes" have been drawing discussion. They are said to improve skin health and may even be used in preventive medicine. So what exactly are exosomes? Are they an organ in the body? Or something that appears out of nowhere? In fact, scientists discovered their existence more than ten years ago, but at first regarded them only as "cellular waste." In recent years, however, research has shown that exosomes can regulate inflammatory responses, promote new blood vessel formation, activate cells, and more! That is why they are now widely used in aesthetic medicine and in the medicine of the future. Today we introduce exosomes in detail. Let's learn about this medical discovery together!

What Are Exosomes?

The human body is made up of cells differentiated from more than 200 types of stem cells, and "exosomes" are nanoscale cellular vesicles continually secreted by these stem cells. In past research, scientists only found that cells constantly secrete tiny bubbles and regarded them as "waste," but recent years have brought new discoveries!

Exosomes are described as playing the role of a mail carrier. They average about 30-200 nm in size and are easily absorbed because the particles are so small. Exosomes also "deliver cargo," bringing healthy cells in time to rescue inflamed or damaged tissue. Exosomes are now also being developed for use in medicine, with work covering Alzheimer's disease, immune system regulation, slowing neurological diseases, and helping wound repair.

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4 Advantages and Effects of Exosomes

Studies show that exosomes offer easy absorption, high compatibility, fast delivery, and high stability, four major advantages. Below we also explain what exosomes can do!

1. Easy absorption: Exosomes are nanoscale particles (about 30-200 nm on average), and their small size makes them easy to absorb.
2. High compatibility: They have a lipid bilayer structure and are highly compatible with other cells.
3. Fast delivery: By carrying messages between cells, they call on other cells for support when a cell becomes abnormal, so healthy cells can carry out regeneration and repair.
4. High stability: They are highly stable and keep their activity even in harsh environments.

Because exosomes have remarkable repair ability, they provide excellent repair benefits for aging tissue. They also have anti-inflammatory, cell-activating, immune-modulating, and regenerative repair functions

Repair Ability

Exosomes can promote collagen growth in the body, speeding up wound healing in the early stage and suppressing collagen production in the late stage of healing, reducing scar formation.

Slowing Aging

Because exosomes are small and easily absorbed, in skin care they can help the skin trigger repair signals that reach the fibroblasts in the dermis directly, achieving moisture locking and brightening from the inside out, soothing sensitive skin that is dry and itchy, and restoring the skin's original radiance and elasticity.

Stimulating Collagen

Exosomes can stimulate the skin to synthesize more collagen. Their nano-sized particles are wrapped in a lipid outer layer and can pass through the epidermis easily, so absorption is faster and moisture is not easily lost, which locks in the skin's nutrients.

Regeneration and Repair

In scalp and hair follicle cells, it can promote hair regeneration, regulate the hair growth cycle, stimulate the proliferation and differentiation of outer root sheath cells, promote the growth and migration of dermal papilla cells, and inhibit apoptosis.

Why Are Exosomes Used in Aesthetic Medicine?

Exosomes are widely used in aesthetic medicine because of three main features:

• Tiny molecules that are easily absorbed.
• Exosomes have a lipid bilayer structure, so they are highly compatible with other cells and can produce some regenerative and repair effects in the body.
• Exosomes are called the mail carriers between cells and can act as a communicator between the two. When skin cells encounter an abnormal situation and send out a distress signal, exosomes guide healthy cells to the site to rescue them!

Exosomes vs. Stem Cells

Exosomes come from stem cells and mainly regulate cell function and behavior by delivering "bioactive molecules," and they can treat many conditions! Also, using exosomes carries lower safety risk than using stem cells, because exosomes do not involve the direct production of new cells! So you can feel very reassured on safety.

Stem cells can differentiate into any type of cell in the body and can be used for treating degenerative diseases and tissue damage, among other uses. However, stem cell treatment is still under study, may face challenges with cell purity and safety, and requires control of the cell differentiation process.

For hair regrowth, many people also compare exosomes with PRP. Let's look at how the two differ!

PRP is short for platelet-rich plasma and is a type of "proliferation therapy." It uses platelets from your own blood to repair damaged tissue and relieve pain. It is commonly used to treat joints, ligaments, and tendons, and is also used in aesthetic medicine for purposes such as skin improvement and hair growth, among others.

P.S. If the protein in your body is insufficient, tissue healing will also be affected, and PRP treatment will be much less effective as well!

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Who Is Exosome Therapy For?

1. People who want to improve pigmentation and dark patches
2. People who want to improve fine lines
3. People who want to improve skin firmness
4. People who want to improve skin quality and even out skin tone
5. People who want to promote scar repair and speed healing

How Exosomes Affect the Skin

The skin makes up seventy percent of the human body and performs important functions such as protecting the body, sweating, and sensing temperature changes. But when skin suffers damage that is hard to heal or severe damage, such as keloids, treatment becomes more difficult and risky overall. Since research in recent years revealed the advantages and functions of exosomes, however, this problem can be greatly eased!

Exosomes play important roles in both the physiology and pathology of the skin, including promoting the release of inflammatory cytokines, speeding up the formation of new blood vessels in damaged areas, accumulating collagen, and promoting fibroblast growth and development, all of which are key to cell repair, and they also effectively inhibit keloid formation.

Exosomes are injected into the subcutaneous tissue through "microneedles" that disrupt the epidermis. Take the traditional skin booster as an example: a week after the procedure, you may experience dehydrated skin as an aftereffect, because the stratum corneum barrier is damaged and the skin cannot lock in moisture right away, so it must rely on the water-absorbing function of hyaluronic acid to maintain hydration. Exosome treatment avoids this problem. The day after treatment, the skin immediately feels brand new, with no downtime! Results last about two months or more, and it offers better value than the commonly heard-of skin booster injections and skin booster guns!

Exosomes and Preventive Medicine

Anti-aging skin research shows that exosomes can easily pass through the stratum corneum and reach the dermis, stimulating type I collagen and elastin in human skin tissue and thereby improving skin texture! The molecular substances wrapped inside exosomes resist breakdown by enzymes in the body, and this characteristic makes exosomes a "new natural drug delivery system."

In cancer immune activation, exosomes also show a unique function. Experiments show that the antigens carried by tumor-derived exosomes can effectively fight tumors and trigger immune responses, thereby achieving an anti-cancer effect. Exosomes therefore have a promising future, and we look forward to research uncovering more advantages and using them in medicine and aesthetic medicine!

Treatments That Can Be Combined with Exosomes

Skin Booster Gun

Nothing is paired with exosome treatment more often than the skin booster series (skin booster gun and skin booster injection). Combining the advantages of the skin booster gun, exosomes and hyaluronic acid serve as the main ingredients to target a variety of skin problems, delivering nutrients deep into the skin for radiance and firmness, boosting collagen, and rebuilding the skin's healthy structure, for a 1+1>2 effect.

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Sylfirm X Radiofrequency

Sylfirm X is the world's only US FDA-approved dual-wave radiofrequency gold microneedle. It uses "radiofrequency thermocoagulation" to produce an electrothermal reaction, working with 24K gold microneedles that target the skin precisely and solve your skin problems at the root. Combined with exosome treatment to awaken dormant cells and repair the skin to the fullest, the age-reversing effect is multiplied!